Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole
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چکیده
منابع مشابه
Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole.
The monogamous prairie vole displays developmental sensitivity to early pharmacological manipulation in a number of species-typical social behaviors. The long-term consequences of altering the neonatal dopamine system are not well characterized. This study examined whether early manipulation of the dopamine system, a known mediator of adult prairie vole social behavior, during neonatal developm...
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Pair bond formation has been investigated much less than many other social behaviors, perhaps in part because traditional laboratory mice and rats do not exhibit this behavior. However, pair bonding is common among monogamous animals such as the prairie vole (Microtus ochrogaster). In this review, we discuss how the prairie vole has been used as a model system to investigate the neurobiology of...
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On postnatal day 8, prairie vole pups were randomly assigned a treatment of 1mg/kg SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, females treated with eticlopride exhibited reduced anxiety-like behavior in an elevated plus maze and a reduction in infanticidal behavior. These behavioral effects were not seen in...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2011
ISSN: 0955-8810
DOI: 10.1097/fbp.0b013e32834affd2